Analytical Data
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Gene name
SNTG1
- Application
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Alternative Names
SNTG1；Gamma-1-syntrophin
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9NSN8
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Expression Region
1-517aa
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AA Sequence
MDFRTACEETKTGICLLQDGNQEPFKVRLHLAKDILMIQEQDVICVSGEPFYSGERTVTIRRQTVGGFGLSIKGGAEHNIPVVVSKISKEQRAELSGLLFIGDAILQINGINVRKCRHEEVVQVLRNAGEEVTLTVSFLKRAPAFLKLPLNEDCACAPSDQSSGTSSPLCDSGLHLNYHPNNTDTLSCSSWPTSPGLRWEKRWCDLRLIPLLHSRFSQYVPGTDLSRQNAFQVIAVDGVCTGIIQCLSAEDCVDWLQAIATNISNLTKHNIKKINRNFPVNQQIVYMGWCEAREQDPLQDRVYSPTFLALRGSCLYKFLAPPVTTWDWTRAEKTFSVYEIMCKILKDSDLLDRRKQCFTVQSESGEDLYFSVELESDLAQWERAFQTATFLEVERIQCKTYACVLESHLMGLTIDFSTGFICFDAATKAVLWRYKFSQLKGSSDDGKSKIKFLFQNPDTKQIEAKELEFSNLFAVLHCIHSFFAAKVACLDPLFLGNQATASTAASSATTSKAKYTT
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Molecular Weight
63.0 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SNTG1, or Syntrophin Gamma 1, is a member of the syntrophin family of proteins that play a crucial role in the assembly and function of dystrophin-associated protein complexes at the neuromuscular junction and in cardiac tissue. This protein is involved in various cellular processes, including signal transduction, cytoskeletal organization, and the modulation of ion channels and receptors. Research has shown that SNTG1 interacts with several key proteins, such as dystrophin and neuronal nitric oxide synthase, which are vital for maintaining muscle integrity and function. Mutations or dysregulation of SNTG1 have been implicated in muscular dystrophies and other neuromuscular disorders, highlighting the importance of understanding its biological activities and molecular mechanisms. The recombinant expression of SNTG1 allows scientists to study its properties in detail, facilitating investigations into its functional roles and interactions in both normal and pathological states. As knowledge of SNTG1 expands, it may offer insights into novel therapeutic strategies for diseases linked to syntrophin dysfunction, underscoring its relevance in muscle biology and potential as a target for drug development. Understanding SNTG1’s structure and function will not only enrich our comprehension of synaptic physiology but also pave the way for advancements in treating neuromuscular disorders.
