Analytical Data
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基因名
RIOK1
- Application
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别名
RIOK1；RIO1；Serine/threonine-Protein kinase RIO1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9BRS2
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表达区间
1-568aa
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氨基酸序列
MDYRRLLMSR VVPGQFDDAD SSDSENRDLK TVKEKDDILF EDLQDNVNEN GEGEIEDEEE EGYDDDDDDW DWDEGVGKLA KGYVWNGGSN PQANRQTSDS SSAKMSTPAD KVLRKFENKI NLDKLNVTDS VINKVTEKSR QKEADMYRIK DKADRATVEQ VLDPRTRMIL FKMLTRGIIT EINGCISTGK EANVYHASTA NGESRAIKIY KTSILVFKDR DKYVSGEFRF RHGYCKGNPR KMVKTWAEKE MRNLIRLNTA EIPCPEPIML RSHVLVMSFI GKDDMPAPLL KNVQLSESKA RELYLQVIQY MRRMYQDARL VHADLSEFNM LYHGGGVYII DVSQSVEHDH PHALEFLRKD CANVNDFFMR HSVAVMTVRE LFEFVTDPSI THENMDAYLS KAMEIASQRT KEERSSQDHV DEEVFKRAYI PRTLNEVKNY ERDMDIIMKL KEEDMAMNAQ QDNILYQTVT GLKKDLSGVQ KVPALLENQV EERTCSDSED IGSSECSDTD SEEQGDHARP KKHTTDPDID KKERKKMVKE AQREKRKNKI PKHVKKRKEK TAKTKKGK
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RIOK1 (RIO kinase 1) is a member of the RIO kinase family, which is implicated in various cellular processes, including ribosome biogenesis, translational control, and response to cellular stress. It has been shown to play a crucial role in the regulation of cell proliferation and differentiation. RIOK1 is characterized by its kinase activity, allowing it to phosphorylate target proteins involved in these processes. Recent studies have identified RIOK1 as a potential player in cancer biology, with alterations in its expression linked to tumor progression and metastasis. Furthermore, RIOK1 has been associated with several signaling pathways, indicating its importance in maintaining cellular homeostasis. The recombinant expression of RIOK1 is essential for understanding its structure-function relationship and the molecular mechanisms underlying its activity. This research not only aims to elucidate the biological functions of RIOK1 but also explores its potential as a therapeutic target in diseases where its dysregulation is observed. By generating RIOK1 recombinant protein, researchers can perform detailed biochemical assays, structural studies, and functional analyses, providing deeper insights into its roles in health and disease. Understanding RIOK1's mechanisms can pave the way for novel interventions in cancer and other disorders related to its dysregulation.
