Analytical Data
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Gene name
SPSB3
- Application
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Alternative Names
SPSB3; C16orf31; SSB3; SPRY domain-containing SOCS box protein 3; SSB-3
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q6PJ21
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Expression Region
1-355aa
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AA Sequence
MARRPRNSRA WHFVLSAARR DADARAVALA GSTNWGYDSD GQHSDSDSDP EYSTLPPSIP SAVPVTGESF CDCAGQSEAS FCSSLHSAHR GRDCRCGEED EYFDWVWDDL NKSSATLLSC DNRKVSFHME YSCGTAAIRG TKELGEGQHF WEIKMTSPVY GTDMMVGIGT SDVDLDKYRH TFCSLLGRDE DSWGLSYTGL LHHKGDKTSF SSRFGQGSII GVHLDTWHGT LTFFKNRKCI GVAATKLQNK RFYPMVCSTA ARSSMKVTRS CASATSLQYL CCHRLRQLRP DSGDTLEGLP LPPGLKQVLH NKLGWVLSMS CSRRKAPVSD PQAATSAHPS SREPRPCQRK RCRRT
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Molecular Weight
39.3 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SPSB3 (Spleen Tyrosine Kinase-Binding Protein 3) is a member of the SPSB family of proteins, which play a crucial role in regulating various cellular processes, including signal transduction, apoptosis, and the immune response. Recent research has highlighted the importance of SPSB3 in modulating the signaling pathways linked to inflammatory responses and its potential involvement in cancer progression. The ability of SPSB3 to interact with different signaling molecules suggests that it may function as an adaptor protein, bridging various pathways and influencing cellular outcomes. Studies have shown that alterations in SPSB3 expression can impact cell proliferation and survival, making it a potential target for therapeutic interventions. Moreover, the characterization of SPSB3 as a target for small molecule inhibitors has opened new avenues for drug development. Given its significant role in disease mechanisms, the production and functional analysis of recombinant SPSB3 protein have gained attention in the context of understanding its structural properties and interactions. Investigating SPSB3 through recombinant techniques not only enhances our understanding of its biological functions but also aids in exploring its potential as a biomarker for diseases like cancer and autoimmune disorders. Overall, the study of SPSB3 and its recombinant protein offers promising insights into novel therapeutic strategies and a deeper understanding of the molecular underpinnings of disease.
