Analytical Data
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基因名
DOCK4
- Application
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别名
DOCK4；KIAA0716；Dedicator of cytokinesis Protein 4
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8N1I0
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表达区间
全长
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氨基酸序列
full
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
DOCK4 (Dedicator of Cytokinesis 4) is a member of the DOCK family of guanine nucleotide exchange factors (GEFs) that play crucial roles in regulating the dynamics of the cytoskeleton, cell migration, and various signaling pathways. Originally identified for its involvement in the process of cytokinesis, recent studies have revealed that DOCK4 is also implicated in various physiological and pathological processes, including immune responses, cancer progression, and neuronal development. The exploration of DOCK4 as a recombinant protein has gained momentum due to its potential as a therapeutic target, particularly in oncology, where its overexpression has been linked to tumorigenesis and metastasis. Additionally, understanding the structure-function relationship of DOCK4 could provide insights into its regulatory mechanisms and interactions with other cellular components. Researchers are focusing on producing and characterizing recombinant DOCK4 proteins to elucidate its biological functions and to investigate its role in cellular processes. By employing techniques such as protein purification and biochemical assays, scientists aim to develop targeted therapies that could mitigate the effects of aberrant DOCK4 signaling in disease contexts. These advancements hold promise for designing innovative strategies in cancer therapy and other diseases where DOCK4 plays a significant role, emphasizing the importance of continued research into this important protein.
