Analytical Data
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基因名
ERBB2IP
- Application
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别名
Densin-180-like protein; Erbb2-interacting protein; Erbb2ip; Erbin; LAP2; LAP2_HUMAN; Protein LAP2
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q96RT1
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表达区间
1272-1371aa
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氨基酸序列
QGHELAKQEIRVRVEKDPELGFSISGGVGGRGNPFRPDDDGIFVTRVQPEGPASKLLQPGDKIIQANGYSFINIEHGQAVSLLKTFQNTVELIIVREVSS
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分子量
36.74 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ERBB2IP (Erb-B2 Receptor Tyrosine Kinase 2 Interacting Protein) is a significant molecule in the field of cancer research due to its interaction with the ErbB2 receptor, which is known to play a crucial role in the development and progression of various cancers, particularly breast cancer. Initial studies identified ERBB2IP as a binding partner of ErbB2, suggesting its involvement in signaling pathways that promote cell proliferation and survival. The overexpression of the ErbB2 receptor has been linked to aggressive tumor characteristics and poor prognosis in patients, highlighting the importance of understanding the molecular mechanisms underlying ErbB2 signaling. Recent research efforts have focused on characterizing the functional roles of ERBB2IP in modulating these pathways, including its influence on receptor localization, stabilization, and downstream signaling events. Additionally, the potential of ERBB2IP as a therapeutic target has garnered attention, with studies exploring the effects of disrupting its interactions within the ErbB2 signaling network. By generating recombinant ERBB2IP proteins, researchers aim to elucidate the structural and functional properties that govern its interactions, thereby paving the way for novel therapeutic strategies and improving the understanding of cancer biology. The study of ERBB2IP thus serves not only as a means to shed light on fundamental cancer mechanisms but also holds promise for enhancing targeted treatment approaches against ErbB2-positive malignancies.
