Analytical Data
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Gene name
ZNF28
- Application
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Alternative Names
ZNF28; KOX24; Zinc finger Protein 28; Zinc finger Protein KOX24
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P17035
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Expression Region
1-718 aa
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AA Sequence
MALPQGLLTF RDVAIEFSQE EWKCLDPAQR TLYRDVMLEN YRNLVSLDIS SKCMMKTFFS TGQGNTEAFH TGTLQRQASH HIGDFCFQKI EKDIHGFQFQ WKEDETNDHA APMTEIKELT GSTGQHDQRH AGNKHIKDQL GLSFHSHLPE LHIFQPEGKI GNQVEKSINN ASSVSTSQRI CCRPKTHISN KYGNNSLHSS LLTQKRNVHM REKSFQCIES GKSFNCSSLL KKHQITHLEE KQCKCDVYGK VFNQKRYLAC HRRSHIDEKP YKCNECGKIF GHNTSLFLHK ALHTADKPYE CEECDKVFSR KSHLETHKII YTGGKPYKCK VCDKAFTCNS YLAKHTIIHT GEKPYKCNEC GKVFNRLSTL ARHRRLHTGE KPYECEECEK VFSRKSHLER HKRIHTGEKP YKCKVCDKAF AYNSYLAKHS IIHTGEKPYK CNECGKVFNQ QSTLARHHRL HTAEKPYKCE ECDKVFRCKS HLERHRRIHT GEKPYKCKVC DKAFRSDSCL TEHQRVHTGE KPYMCNECGK VFSTKANLAC HHKLHTAEKP YKCEECEKVF SRKSHMERHR RIHTGEKPYK CKVCDKAFRR DSHLAQHQRV HTGEKPYKCN ECGKTFRQTS SLIIHRRLHT GEKPYKCNEC GKTFSQMSSL VYHHRLHSGE KPYKCNECGK VFNQQAHLAQ HQRVHTGEKP YKCNECGKTF SQMSNLVYHH RLHSGEKP
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Molecular Weight
83.6 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ZNF28, a member of the zinc finger protein family, has attracted considerable research interest due to its potential role in regulating gene expression and its involvement in various biological processes, including cell differentiation and proliferation. Initially identified in studies focusing on developmental biology, ZNF28 has been implicated in diverse cellular functions and is thought to play a critical role in the transcriptional regulation of target genes. Its unique structure, characterized by multiple zinc finger motifs, suggests that ZNF28 may interact with DNA in a sequence-specific manner, influencing chromatin organization and gene accessibility. Recent studies have also highlighted the potential involvement of ZNF28 in pathological conditions, including cancer, where its expression levels and functional roles may differ significantly from normal tissue. Additionally, the development and purification of ZNF28 recombinant protein have opened new avenues for understanding its molecular interactions and mechanisms of action. By using techniques such as yeast two-hybrid screening, co-immunoprecipitation, and various biochemical assays, researchers aim to elucidate the functional properties of ZNF28, leading to insights into its contributions to cellular homeostasis and the underlying mechanisms of disease. As the understanding of ZNF28's role in cellular processes continues to evolve, it holds promise not only as a key regulator in fundamental biological research but also as a potential target for therapeutic intervention in diseases linked to dysregulation of its expression or function. This positions ZNF28 as a significant focus within the field of molecular biology and genetics, driving continued investigation into its properties and applications in health and disease.
