Analytical Data
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Gene name
FBXO16
- Application
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Alternative Names
FBXO16; FBX16; F-box only protein 16
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8IX29
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Expression Region
1-292aa
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AA Sequence
MMAFAPPKNT DGPKMQTKMS TWTPLNHQLL NDRVFEERRA LLGKWFDKWT DSQRRRILTG LLERCSLSQQ KFCCRKLQEK IPAEALDFTT KLPRVLSLYI FSFLDPRSLC RCAQVCWHWK NLAELDQLWM LKCLRFNWYI NFSPTPFEQG IWKKHYIQMV KELHITKPKT PPKDGFVIAD VQLVTSNSPE EKQSPLSAFR SSSSLRKKNN SGEKALPPWR SSDKHPTDII RFNYLDNRDP METVQQGRRK RNQMTPDFSR QSHDKKNKLQ DRTRLRKAQS MMSRRNPFPL CP
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Molecular Weight
34.5 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
FBXO16 is a member of the F-box protein family, which plays a crucial role in the ubiquitin-proteasome system, a key pathway for protein degradation in cells. The function of FBXO16 primarily involves its ability to recognize and bind specific substrates for ubiquitination, thereby regulating various cellular processes such as cell division, differentiation, and response to stress. Recent studies have highlighted the potential implications of FBXO16 in various diseases, including cancer, where its dysregulation may contribute to tumorigenesis and metastasis. Additionally, FBXO16 has been associated with the regulation of circadian rhythms, suggesting its involvement in maintaining cellular homeostasis and adaptation to environmental changes. Understanding the molecular mechanisms by which FBXO16 operates may provide insights into its role in health and disease, paving the way for potential therapeutic interventions targeting its pathway. Given the increasing interest in the development of ubiquitin-based therapies, FBXO16 stands out as a promising candidate for further investigation in the realm of protein homeostasis and disease management.
