Analytical Data
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Gene name
HRH3
- Application
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Alternative Names
HRH3；GPCR97；Histamine H3 receptor
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9Y5N1
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Expression Region
1-445aa
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AA Sequence
MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAAGPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSVASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSLAVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLLCPQKLKIQPHSSLEHCWK
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HRH3, or Histamine Receptor H3, is a G-protein coupled receptor predominantly found in the brain and plays a crucial role in regulating neurotransmitter release, particularly histamine neurotransmission. As a major player in modulating cognitive functions, such as learning, memory, and arousal, HRH3 has garnered significant interest in pharmacological research, particularly for its potential therapeutic applications in neurodegenerative diseases, sleep disorders, and psychiatric conditions. Research on recombinant HRH3 protein involves the expression, purification, and functional characterization of this receptor to better understand its structure-function relationships and interactions with various ligands. The ability to produce HRH3 in a recombinant form allows for detailed in vitro studies, paving the way for the development of selective HRH3 antagonists or agonists that could serve as novel drug candidates. Additionally, understanding the signaling pathways associated with HRH3 can elucidate its role in pathophysiological conditions, highlighting its potential as a target for innovative treatments. The ongoing exploration of HRH3 recombinant proteins is essential not only for basic science but also for advancing therapeutic strategies addressing a range of neurological and psychological disorders.
