Analytical Data
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基因名
FOSB
- Application
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别名
FosB proto-oncogene. AP-1 transcription factor subunit;G0/G1 switch regulatory protein 3;Transcription factor AP-1 subunit FosB
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P53539
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表达区间
1-338aa
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氨基酸序列
MFQAFPGDYDSGSRCSSSPSAESQYLSSVDSFGSPPTAAASQECAGLGEMPGSFVPTVTAITTSQDLQWLVQPTLISSMAQSQGQPLASQPPVVDPYDMPGTSYSTPGMSGYSSGGASGSGGPSTSGTTSGPGPARPARARPRRPREETLTPEEEEKRRVRRERNKLAAAKCRNRRRELTDRLQAETDQLEEEKAELESEIAELQKEKERLEFVLVAHKPGCKIPYEEGPGPGPLAEVRDLPGSAPAKEDGFSWLLPPPPPPPLPFQTSQDAPPNLTASLFTHSEVQVLGDPFPVVNPSYTSSFVLTCPEVSAFAGAQRTSGSDQPSDPLNSPSLLAL
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分子量
40.0 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
FOSB is a member of the Fos family of transcription factors, which play critical roles in cellular processes such as proliferation, differentiation, and apoptosis. Initially discovered as immediate early genes in response to growth factors and various stimuli, FOSB is known for its involvement in oncogenesis and its regulation of genes associated with neural activity and plasticity. The protein functions by forming heterodimers with Jun proteins, leading to the activation of target genes via specific promoter sequences. Research has shown that altered expression and activity of FOSB is linked to several pathological conditions, including cancer and neurodegenerative diseases. As such, the study of FOSB and its recombinant protein forms has gained significant attention, particularly in understanding its molecular mechanisms and potential roles as therapeutic targets. Researchers aim to elucidate the functional implications of FOSB in different biological contexts, exploring its potential as a biomarker for disease progression and as a candidate for novel treatment approaches. Through recombinant protein technology, scientists are investigating the structure, interactions, and regulatory mechanisms of FOSB, paving the way for innovations in medical science and biotechnology.
