Analytical Data
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基因名
Psmc1
- Application
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别名
P26s4; 26S proteasome AAA-ATPase subunit RPT2
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种属
Mouse
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表达系统
E. coli
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标签
N-terminal His and Tag
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P62192
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表达区间
1-440aa
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氨基酸序列
MGQSQSGGHGPGGGKKDDKDKKKKYEPPVPTRVGKKKKKTKGPDAASKLPLVTP HTQCRLKLLKLERIKDYLLMEEEFIRNQEQMKPLEEKQEEERSKVDDLRGTPMS VGTLEEIIDDNHAIVSTSVGSEHYVSILSFVDKDLLEPGCSVLLNHKVHAVIGV LMDDTDPLVTVMKVEKAPQETYADIGGLDNQIQEIKESVELPLTHPEYYEEMGI KPPKGVILYGPPGTGKTLLAKAVANQTSATFLRVVGSELIQKYLGDGPKLVREL FRVAEEHAPSIVFIDEIDAIGTKRYDSNSGGEREIQRTMLELLNQLDGFDSRGD VKVIMATNRIETLDPALIRPGRIDRKIEFPLPDEKTKKRIFQIHTSRMTLADDV TLDDLIMAKDDLSGADIKAICTEAGLMALRERRMKVTNEDFKKSKENVLYKKQE GTPEGLYL
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分子量
52.5 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Psmc1, also known as Proteasome 26S subunit, is a vital component of the 26S proteasome, which plays a crucial role in the ubiquitin-proteasome pathway responsible for protein degradation within cells. This pathway maintains proteostasis, regulates various cellular processes, and is involved in the degradation of misfolded or damaged proteins, thereby preventing the accumulation of potentially toxic aggregates. Research into Psmc1 has gained significant attention due to its implications in several diseases, including cancer and neurodegenerative disorders, where proteasomal dysfunction is often observed. Psmc1 functions as part of the ATPase complex in the proteasome, facilitating the unfolding and translocation of substrates into the catalytic core for degradation. Given its essential role in cellular homeostasis, understanding the structure and function of Psmc1 through recombinant protein studies is pivotal. Such studies enhance our knowledge of proteasome regulation and its interactions with various substrates, paving the way for therapeutic interventions that target the proteasome system. Researchers are focusing on the production and characterization of recombinant Psmc1 to explore its mechanistic roles and potential as a target for drug development, particularly in conditions marked by proteasome inhibition or dysfunction.
