Analytical Data
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基因名
GMPPA
- Application
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别名
GDP mannose pyrophosphorylase A; GDP-mannose pyrophosphorylase A; Gmppa; GMPPA_HUMAN; GTP mannose 1 phosphate guanylyltransferase alpha; GTP-mannose-1-phosphate guanylyltransferase alpha; Mannose 1 phosphate guanylyltransferase (GDP); Mannose-1-phosphate guanyltransferase alpha
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q96IJ6
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表达区间
1-420aa
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氨基酸序列
MLKAVILIGGPQKGTRFRPLSFEVPKPLFPVAGVPMIQHHIEACAQVPGMQEILLIGFYQPDEPLTQFLEAAQQEFNLPVRYLQEFAPLGTGGGLYHFRDQILAGSPEAFFVLNADVCSDFPLSAMLEAHRRQRHPFLLLGTTANRTQSLNYGCIVENPQTHEVLHYVEKPSTFISDIINCGIYLFSPEALKPLRDVFQRNQQDGQLEDSPGLWPGAGTIRLEQDVFSALAGQGQIYVHLTDGIWSQIKSAGSALYASRLYLSRYQDTHPERLAKHTPGGPWIRGNVYIHPTAKVAPSAVLGPNVSIGKGVTVGEGVRLRESIVLHGATLQEHTCVLHSIVGWGSTVGRWARVEGTPSDPNPNDPRARMDSESLFKDGKLLPAITILGCRVRIPAEVLILNSIVLPHKELSRSFTNQIIL
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分子量
72.7 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GMPPA (Gamma-Glutamyl Phosphate Synthetase) is an essential enzyme involved in the biosynthesis of nucleotides and amino acids, playing a critical role in cellular metabolism. Its importance is underscored by its involvement in the synthesis of gamma-glutamyl phosphate, a key precursor for various biochemical pathways. Research into GMPPA has gained momentum due to its potential therapeutic implications in diseases such as cancer and metabolic disorders, where alterations in nucleotide metabolism are often observed. Furthermore, GMPPA is implicated in the regulation of several crucial cellular functions, including cell growth, differentiation, and apoptosis. The study of GMPPA as a recombinant protein allows for detailed characterization of its enzymatic activity, structure, and interaction with other cellular components. The production of GMPPA in recombinant systems provides a valuable tool for understanding its mechanisms of action and could pave the way for the development of targeted therapies that modulate its activity. As researchers delve into the structural biology of GMPPA, insights gained could lead to innovations in drug design and treatment strategies for metabolic diseases. Overall, the exploration of GMPPA through recombinant protein research not only enhances our fundamental understanding of cellular metabolism but also opens new avenues for biomedical applications aimed at improving human health.
