Analytical Data
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基因名
FGFR-3 beta (IIIc)
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简介
The FGFR-3 protein is a tyrosine-protein kinase receptor for fibroblast growth factor that is critical for cellular processes, particularly in chondrocytes, osteoblasts, and inner ear development. Its effects span normal skeletal development and postnatal bone mineralization. FGFR-3 beta (IIIc) Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived FGFR-3 beta IIIc protein, expressed by HEK293 , with C-Avi, C-His labeled tag.
- Application
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别名
ACH; CD333; CEK; CEK2; EC 2.7.10; FGF R3; FGFR3; HSFGFR3EX; JTK4
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种属
Human
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表达系统
HEK293
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标签
C-Avi;C-8*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P22607-1
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表达区间
D127-G375
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蛋白长度
Partial
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分子量
50-60 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Fibroblast growth factor receptor 3 (FGFR3) is a crucial receptor involved in various cellular processes, including proliferation, differentiation, and apoptosis. Of particular interest is the β-isoform, also known as FGFR3b (IIIc), which plays a significant role in skeletal development and homeostasis. Mutations in the FGFR3 gene are associated with various skeletal disorders, such as achondroplasia, a common form of dwarfism. Research into FGFR3b has gained momentum as scientists seek to understand the molecular mechanisms underlying these conditions and develop targeted therapies. The recombinant FGFR3b protein allows for in-depth studies of its structure, function, and interaction with ligands, facilitating insights into its signaling pathways and their alterations in disease states. Such studies have the potential to inform therapeutic approaches that can modulate FGFR3 activity, offering hope for treatments for skeletal dysplasias and related conditions. By elucidating the role of FGFR3b in cellular and developmental biology, researchers aim to pave the way for innovative interventions that can mitigate the effects of FGFR3-related disorders.
