Analytical Data
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基因名
TNFRSF10C
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简介
TRAILR4/TNFRSF10D protein is a receptor for TRAIL and lacks the ability to induce apoptosis due to the truncated death domain. Paradoxically, not only does it fail to induce apoptosis, but it also prevents TRAIL-mediated apoptosis. TRAILR4/TNFRSF10D Protein, Human (HEK293, Fc) is the recombinant human-derived TRAILR4/TNFRSF10D protein, expressed by HEK293 , with C-hFc labeled tag.
- Application
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别名
Tumor necrosis factor receptor superfamily member 10D; DcR2; TRAIL receptor 4; TRAIL-R4; CD264; TNFRSF10D; DCR2; TRAILR4; TRUNDD
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种属
Human
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表达系统
HEK293
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标签
C-hFc
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9UBN6
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表达区间
A56-H211
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蛋白长度
Extracellular Domain
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分子量
50-70 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TNFRSF10C, also known as TRAIL receptor 2 (TRAIL-R2), is a member of the tumor necrosis factor receptor superfamily. This protein is primarily involved in modulating apoptosis, particularly in cancer cells, by mediating the effects of TRAIL (TNF-related apoptosis-inducing ligand). Research has indicated that TNFRSF10C can elicit pro-apoptotic signals when activated by its ligands, making it a potential target for cancer therapy. Preliminary studies suggest that enhancing the expression or activity of TNFRSF10C may increase the sensitivity of tumor cells to TRAIL-induced apoptosis, therefore offering a novel strategy for cancer treatment. Moreover, alterations in TNFRSF10C expression levels have been associated with various malignancies, indicating its role in tumorigenesis and the progression of certain cancers. The development and application of recombinant TNFRSF10C proteins have emerged as promising avenues for both understanding its biological functions and exploring therapeutic possibilities, including the design of TRAIL receptor agonists or combination therapies that could improve patient outcomes. Current research is focused on elucidating the structural and functional properties of TNFRSF10C, with the aim of optimizing its application in clinical settings. Additionally, investigating the signaling pathways activated by TNFRSF10C may provide new insights into its role in immune regulation and anticancer immunity, thereby expanding its potential use in combination with other immunotherapeutic approaches.
