Analytical Data
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Gene name
IL-18RAP
- Application
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Biological Activity
Rhesus Macaque IL-18RAP immobilized on CM5 Chip can bind Human IL-18Rα (Premixed with Human IL-18) with an affinity constant of 13.37 nM as determined in a SPR assay. Rhesus Macaque IL-18RAP immobilized on CM5 Chip can bind Human IL-18Rα (Premixed with Human IL-18) with an affinity constant of 13.37 nM as determined in a SPR assay.
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Alternative Names
Interleukin-18 receptor accessory protein; CDw218b; IL-1R7; IL-18R-beta; CD218b
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Species
Rhesus Macaque
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Source
HEK293
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Tag
C-6*His
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Purity
Greater than 95% as determined by reducing SDS-PAGE. as determined by SDS-PAGE.
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Uniprot
XP_001108108.1
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Expression Region
F20-R356
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AA Sequence
FNISGCSTKKFLWAYSTRSEEEFILFCDLPEPQKSHFCHRSQLSPTQVPDHLPFTDSKDLPDVQWYRQPSNGDPLEDIRKSYPHIIQDKCTLRFLTPGVNNTGSYICRPKMIKSPYDVACCVKMILEVKPQSNASCENSASHKQDLLLGSTGSISCPSLSCQSDAQSPEVTWYKNGKLLSMTRSNRIVVDEVYIYHQGTYVCDYTQSDTASSWTVRAVVQVRTIVGDTKLKPDILDPVESTLEVELGKPLTISCKARFGFERVFNPVMKWYIKDADLEWEVSVPEAKSIKSTLKDEIIERNIILEKVTQRDLRRTFVCFVQNSIGNTTQSVQLKEKR
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Protein Length
Partial
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Molecular Weight
52-75 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
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Protein Description
Interleukin-18 receptor accessory protein (IL-18RAP) plays a crucial role in the immune response as it acts as a co-receptor for IL-18, a pro-inflammatory cytokine that enhances the activities of T cells and Natural Killer (NK) cells. Research on IL-18 and its receptor system has gained momentum due to the increasing understanding of their involvement in various inflammatory and autoimmune diseases, as well as in infections and cancer. The IL-18/IL-18RAP signaling pathway is essential for mediating the host's defense against pathogens and for regulating immune responses. Consequently, IL-18RAP has emerged as a potential target for therapeutic interventions aimed at modulating immune responses. Recombinant IL-18RAP protein has become a valuable tool for studying the mechanistic roles of this co-receptor in cellular signaling and for exploring its potential as a biomarker or therapeutic agent. The investigation of IL-18RAP not only deepens our understanding of immune regulation but also paves the way for innovative strategies in treating diseases characterized by dysregulated immune responses.
