Analytical Data
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Gene name
CD204/MSR1
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简介
CD204/MSR1 Protein, a membrane glycoprotein, crucially contributes to cholesterol accumulation in arterial walls during atherogenesis. With two receptor subunits, it facilitates endocytosis of various macromolecules, including modified low-density lipoproteins (LDL). As a homotrimer, CD204/MSR1 engages in key interactions, including its association with MYO18A, highlighting its functional role in cellular processes. CD204/MSR1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived CD204/MSR1 protein, expressed by HEK293 , with N-His labeled tag.
- Application
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Biological Activity
Measured by its binding ability in a functional ELISA. Immobilized Recombinant Mouse CD204 at 5 µg/mL (100 µL/well) can bind biotinylated advanced glycation endproducts of bovine serum albumin (AGE-BSA). The ED50 for this effect is 92.81 ng/mL. Measured by its binding ability in a functional ELISA. Immobilized Recombinant Mouse CD204 at 5 µg/mL (100 µL/well) can bind biotinylated advanced glycation endproducts of bovine serum albumin (AGE-BSA) .The ED50 for this effect is 92.81 ng/mL
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Alternative Names
Macrophage scavenger receptor types I and II; SCARA1
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Species
Mouse
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Source
HEK293
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
AAH03814.1
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Expression Region
W83-V354
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AA Sequence
WEMKNCLVCSLNTSDTSQGPMEKENTSKVEMRFTIIMEHMKDMEERIESISNSKADLIDTERFQNFSMATDQRLNDILLQLNSLISSVQEHGNSLDAISKSLQSLNMTLLDVQLHTETLNVRVRESTAKQQEDISKLEERVYKVSAEVQSVKEEQAHVEQEVKQEVRVLNNITNDLRLKDWEHSQTLKNITFIQGPPGPQGEKGDRGLTGQTGPPGAPGIRGIPGVKGDRGQIGFPGGRGNPGAPGKPGRSGSPGPKGQKGEKGSVGGSRSV
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Protein Length
Partial
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Molecular Weight
42-75 kDa.
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CD204, also known as macrophage scavenger receptor 1 (MSR1), plays a crucial role in the immune system by mediating the recognition and clearance of modified lipoproteins and pathogens. Its involvement in various physiological and pathological processes, such as atherosclerosis, inflammation, and tissue repair, has garnered significant attention in biomedical research. Receptor engagement activates intracellular signaling pathways that influence macrophage polarization and immune responses. Consequently, the recombinant expression of CD204/MSR1 provides a valuable tool for studying its function and potential therapeutic applications. Researchers have focused on producing high-quality recombinant proteins to facilitate in vitro studies and functional assays, enabling detailed investigations into ligand-receptor interactions and the receptor’s role in disease. Furthermore, understanding the structure-function relationship of CD204/MSR1 can pave the way for the development of novel therapeutic strategies targeting this receptor in various diseases, making it a key subject of interest in immunology and therapeutic research.
