Analytical Data
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基因名
CD163
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简介
The CD163 protein is critical in macrophages for clearance and endocytosis of hemoglobin/haptoglobin complexes, protecting tissues from oxidative damage. It promotes iron recycling by promoting complex endocytosis and heme breakdown, while calcium and pH affect hemoglobin binding. CD163 Protein, Mouse (HEK293, His) is the recombinant mouse-derived CD163 protein, expressed by HEK293 , with C-His labeled tag.
- Application
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别名
M130; CD163 molecule; CD163; GHI/61; HbSR; MM130; RM3/1; SCARI1; sCD163
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种属
Mouse
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表达系统
HEK293
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标签
C-8*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q2VLH6-1
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表达区间
V39-T1045
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蛋白长度
Extracellular Domain
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分子量
120-150 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CD163 is a type I transmembrane glycoprotein predominantly expressed on the surface of monocytes and macrophages. It serves as a receptor for hemoglobin-haptoglobin complexes and plays a crucial role in anti-inflammatory responses and immune regulation. Research on CD163 has gained significant interest due to its involvement in various physiological and pathological processes, including tissue repair, the regulation of inflammatory responses, and the modulation of autoimmune diseases. Alterations in CD163 expression have been linked to several conditions, such as cardiovascular diseases, chronic inflammatory diseases, and certain cancers. The soluble form of CD163 (sCD163) released from macrophages into circulation has emerged as a potential biomarker for disease progression and severity. As a result, recombinant CD163 protein is crucial for further studies aiming to elucidate its functional mechanisms, potential therapeutic applications, and its role in disease pathogenesis. Studies using recombinant CD163 can provide insights into its interactions with various ligands and its impact on macrophage polarization, which in turn could lead to novel therapeutic strategies targeting inflammatory diseases and enhancing immune responses in cancer therapy. Understanding the detailed biology of CD163 through recombinant protein studies holds promise for developing innovative approaches in both diagnostics and therapeutics.
