Analytical Data
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Gene name
DLL1
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简介
Delta-like protein 1 (DLL1) is a transmembrane ligand for NOTCH1, NOTCH2, and NOTCH3 receptors and participates in cis- and trans-interactions with their extracellular domains. Upon interaction, DLL1 induces mechanical forces that promote Notch signaling by triggering NICD nuclear accumulation. Delta-like protein 1/DLL1 Protein, Rat (HEK293, His) is the recombinant rat-derived Delta-like protein 1/DLL1 protein, expressed by HEK293 , with C-His labeled tag.
- Application
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Alternative Names
Delta-like protein 1; Delta1; Dll1-EC; Dll1-TMIC; Dll1
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Species
Rat
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Source
HEK293
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Tag
C-10*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P97677
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Expression Region
Q18-S534
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AA Sequence
QVWSSGVFELKLQEFVNKKGLLGNRNCCRGGSGPPCACRTFFRVCLKHYQASVSPEPPCTYGSAVTPVLGVDSFSLPDGAGIDPAFSNPIRFPFGFTWPGTFSLIIEALHTDSPDDLATENPERLISRLTTQRHLTVGEEWSQDLHSSGRTDLRYSYRFVCDEHYYGEGCSVFCRPRDDAFGHFTCGERGEKMCDPGWKGQYCTDPICLPGCDDQHGYCDKPGECKCRVGWQGRYCDECIRYPGCLHGTCQQPWQCNCQEGWGGLFCNQDLNYCTHHKPCRNGATCTNTGQGSYTCSCRPGYTGANCELEVDECAPSPCRNGGSCTDLEDSYSCTCPPGFYGKVCELSAMTCADGPCFNGGRCSDNPDGGYTCHCPAGFSGFNCEKKIDLCSSSPCSNGAKCVDLGNSYLCRCQTGFSGRYCEDNVDDCASSPCANGGTCRDSVNDFSCTCPPGYTGRNCSAPVSRCEHAPCHNGATCHQRGQRYMCECAQGYGGANCQFLLPEPPPDLIVAAQGGS
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Protein Length
Extracellular Domain
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Molecular Weight
55-60 kDa.
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
DLL1 (Delta-like ligand 1) is an important component of the Notch signaling pathway, which plays a critical role in various biological processes, including cell differentiation, proliferation, and apoptosis. DLL1 acts as a ligand that binds to Notch receptors on adjacent cells, thereby influencing cell fate decisions during embryonic development and tissue homeostasis. Research into DLL1 recombinant proteins has gained momentum due to their potential therapeutic applications in regenerative medicine, cancer immunotherapy, and tissue engineering. By producing DLL1 in a recombinant form, researchers can better study its structural properties and functional mechanisms, paving the way for targeted therapies that manipulate the Notch pathway. Additionally, understanding the precise interactions of DLL1 with its receptors and other signaling molecules can provide insights into various diseases characterized by aberrant cell signaling, such as cancers and developmental disorders. This growing interest in DLL1 recombinant proteins underscores their significance as both a biochemical tool and a potential therapeutic agent, driving further exploration of their role in cell communication and developmental biology.
