Analytical Data
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基因名
KIR2DL3
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简介
KIR2DL3, found on NK cells, selectively recognizes HLA-C alleles like HLA-Cw1, HLA-Cw3, and HLA-Cw7. Its interaction leads to inhibitory effects, preventing NK cell activity and cell lysis. KIR2DL3's association with ARRB2 underscores its role in cellular signaling pathways, intricately modulating NK cell functions. KIR2DL3 Protein, Human (HEK293, His) is the recombinant human-derived KIR2DL3 protein, expressed by HEK293 , with C-6*His labeled tag.
- Application
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种属
Human
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表达系统
HEK293
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标签
C-6*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P43628-1
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表达区间
H22-H245
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氨基酸序列
HEGVHRKPSLLAHPGPLVKSEETVILQCWSDVRFQHFLLHREGKFKDTLHLIGEHHDGVSKANFSIGPMMQDLAGTYRCYGSVTHSPYQLSAPSDPLDIVITGLYEKPSLSAQPGPTVLAGESVTLSCSSRSSYDMYHLSREGEAHERRFSAGPKVNGTFQADFPLGPATHGGTYRCFGSFRDSPYEWSNSSDPLLVSVTGNPSNSWPSPTEPSSETGNPRHLH
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蛋白长度
Extracellular Domain
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分子量
35-50 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
KIR2DL3, part of the Killer Immunoglobulin-like Receptor (KIR) family, is a significant receptor expressed on natural killer (NK) cells and certain T cells, playing a pivotal role in the immune response against infections and tumors. Its primary function involves recognizing specific ligands on target cells, particularly HLA-C molecules, which helps regulate NK cell activity and contributes to immune tolerance and surveillance. The study of KIR2DL3 has gained attention due to its implications in various health conditions, including autoimmune diseases, organ transplantation compatibility, and cancer immunotherapy. Researchers are particularly interested in understanding the structural and functional aspects of KIR2DL3 reconstituted proteins to elucidate the receptor's signaling pathways and its interactions with ligands. This can provide valuable insights into how variations in KIR2DL3 affect immune responses across different populations and genetic backgrounds. Additionally, the development of KIR2DL3 recombinant proteins facilitates the exploration of potential therapeutic applications, including the design of tailored immunotherapies that enhance NK cell activity against tumors. As KIR2DL3's diverse roles in immunity are unraveled, it holds promise for advancing personalized medicine approaches that leverage immune modulation for better disease outcomes.
