Analytical Data
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Gene name
AMHR2/MISRII
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简介
The AMHR2/MISRII protein assembles receptor complexes with two type II and two type I transmembrane serine/threonine kinases upon ligand binding. Type II receptors initiate a signaling cascade that phosphorylates and activates type I receptors, which become autophosphorylated. AMHR2/MISRII Protein, Cynomolgus/Rhesus macaque (HEK293, His) is the recombinant cynomolgus, Rhesus Macaque-derived AMHR2/MISRII protein, expressed by HEK293 , with C-His labeled tag. The total length of AMHR2/MISRII Protein, Cynomolgus/Rhesus macaque (HEK293, His) is 127 a.a., with molecular weight of 20-30 kDa.
- Application
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Alternative Names
MIS RII; MRII; AMHR2; AMHR; MISR2; AMH type II receptor
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Species
Cynomolgus; Rhesus Macaque
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Source
HEK293
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Tag
C-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
A0A2K5U1R9
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Expression Region
P18-S144
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Molecular Weight
20-30 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
AMHR2 (Anti-Müllerian Hormone Receptor Type 2) and MISRII (Müllerian Inhibiting Substance Type II Receptor) are critical components of the reproductive system, primarily involved in the regulation of sexual differentiation and reproductive function. AMHR2 is the receptor for Anti-Müllerian Hormone (AMH), a key hormone in the development of male and female reproductive structures during embryonic development. The interaction between AMH and its receptor prevents the formation of female reproductive organs in males, serving a crucial role in testicular development and spermatogenesis. Disruptions in AMH signaling through AMHR2 have been associated with various reproductive disorders, such as polycystic ovary syndrome (PCOS), testicular dysgenesis, and infertility. A recombinant form of AMHR2/MISRII has been developed to better understand its structural and functional properties, elucidate its role in reproductive biology, and explore its potential as a therapeutic target. Research on this recombinant protein enables investigations into receptor-ligand interactions, signaling pathways, and the molecular mechanisms underlying reproductive health and disease. By providing insights into the AMH pathway, studies involving AMHR2/MISRII recombinant protein could pave the way for novel treatments for reproductive disorders and enhance our understanding of sexual differentiation.
