Analytical Data
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基因名
AMHR2/MISRII
- Application
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别名
MIS type II receptor; MISRII; MRII; AMHR; MISR2; AMHR2; AMH type II receptor; AMHR2; AMHRII; C14
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种属
Rhesus Macaque; Cynomolgus
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表达系统
HEK293
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标签
C-hFc
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
XP_001105261
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表达区间
P18-S144
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蛋白长度
Partial
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分子量
55-60 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
AMHR2 (Anti-Müllerian Hormone Receptor Type 2) and MISRII (Müllerian Inhibiting Substance Type II Receptor) are critical components of the reproductive system, primarily involved in the regulation of sexual differentiation and reproductive function. AMHR2 is the receptor for Anti-Müllerian Hormone (AMH), a key hormone in the development of male and female reproductive structures during embryonic development. The interaction between AMH and its receptor prevents the formation of female reproductive organs in males, serving a crucial role in testicular development and spermatogenesis. Disruptions in AMH signaling through AMHR2 have been associated with various reproductive disorders, such as polycystic ovary syndrome (PCOS), testicular dysgenesis, and infertility. A recombinant form of AMHR2/MISRII has been developed to better understand its structural and functional properties, elucidate its role in reproductive biology, and explore its potential as a therapeutic target. Research on this recombinant protein enables investigations into receptor-ligand interactions, signaling pathways, and the molecular mechanisms underlying reproductive health and disease. By providing insights into the AMH pathway, studies involving AMHR2/MISRII recombinant protein could pave the way for novel treatments for reproductive disorders and enhance our understanding of sexual differentiation.
