Analytical Data
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Gene name
EIF4H
- Application
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Alternative Names
WBSCR1; WSCR1; Williams-Beuren Syndrome Chromosome Region 1
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q15056
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Expression Region
Ala2~Glu248
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Molecular Weight
31kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
EIF4H (Eukaryotic Translation Initiation Factor 4H) is an essential protein involved in the initiation phase of mRNA translation, which is a critical step in gene expression regulation. It plays a pivotal role in the unwinding of mRNA secondary structures, facilitating the recruitment of ribosomes for protein synthesis. Research on EIF4H has gained significance due to its involvement in various cellular processes, including cell growth, differentiation, and response to stress. Aberrations in EIF4H function have been linked to various diseases, including cancers and neurodegenerative disorders. The study of recombinant EIF4H proteins allows researchers to investigate its structural and functional properties in detail, providing insights into its mechanism of action in translation initiation and its regulatory roles in the cell. Furthermore, understanding the interactions of EIF4H with other initiation factors and mRNA molecules can reveal potential therapeutic targets for diseases associated with translation dysregulation. Thus, the development of recombinant EIF4H proteins represents a crucial step towards elucidating the complexities of protein synthesis and its implications in health and disease.
