Analytical Data
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Gene name
AMHR2/MISRII
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简介
The AMHR2/MISRII protein assembles receptor complexes with two type II and two type I transmembrane serine/threonine kinases upon ligand binding. Type II receptors initiate signaling cascades by phosphorylating and activating type I receptors, which undergo autophosphorylation. AMHR2/MISRII Protein, Mouse (HEK293, His) is the recombinant mouse-derived AMHR2/MISRII protein, expressed by HEK293 , with C-His labeled tag.
- Application
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Biological Activity
Measured by its binding ability in a functional ELISA. Immobilized Human rhMIS at 3 μg/mL (100μL/well) can bind Biotinylated Mouse AMHR2. The ED50 for this effect is 240.7 ng/mL. Measured by its binding ability in a functional ELISA. Immobilized Human rhMIS at 3 μg/mL (100μL/well) can bind Biotinylated Mouse AMHR2 .The ED50 for this effect is 240.7 ng/mL.
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Alternative Names
MIS RII; MRII; AMHR2; AMHR; MISR2; AMH type II receptor
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Species
Mouse
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Source
HEK293
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Tag
C-His
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Purity
Greater than 95% as determined by SDS-PAGE.
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Uniprot
Q8K592
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Expression Region
Q16-M147
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Protein Length
Extracellular Domain
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Molecular Weight
25 kDa & 30 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
AMHR2 (Anti-Müllerian Hormone Receptor Type 2) and MISRII (Müllerian Inhibiting Substance Type II Receptor) are critical components of the reproductive system, primarily involved in the regulation of sexual differentiation and reproductive function. AMHR2 is the receptor for Anti-Müllerian Hormone (AMH), a key hormone in the development of male and female reproductive structures during embryonic development. The interaction between AMH and its receptor prevents the formation of female reproductive organs in males, serving a crucial role in testicular development and spermatogenesis. Disruptions in AMH signaling through AMHR2 have been associated with various reproductive disorders, such as polycystic ovary syndrome (PCOS), testicular dysgenesis, and infertility. A recombinant form of AMHR2/MISRII has been developed to better understand its structural and functional properties, elucidate its role in reproductive biology, and explore its potential as a therapeutic target. Research on this recombinant protein enables investigations into receptor-ligand interactions, signaling pathways, and the molecular mechanisms underlying reproductive health and disease. By providing insights into the AMH pathway, studies involving AMHR2/MISRII recombinant protein could pave the way for novel treatments for reproductive disorders and enhance our understanding of sexual differentiation.
