Analytical Data
-
Gene name
AKAP2
- Application
-
Alternative Names
AKAPKL; PALM2; PRKA2; A Kinase(PRKA)Anchor Protein 2; Protein Kinase A2; Protein kinase A-anchoring protein 2
-
Species
Human
-
Source
E. coli
-
Tag
N-His
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
Q9Y2D5
-
Expression Region
Met1~Pro235
-
Molecular Weight
44kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
A-kinase anchoring protein 2 (AKAP2) is a member of the AKAP family, which plays a crucial role in the spatial and temporal regulation of protein kinase A (PKA) signaling. Research has shown that AKAP2 is involved in various cellular processes, including cardiac function, cell adhesion, and the response to stress. Its ability to tether PKA to specific subcellular locations allows for localized signaling, which is essential for maintaining cellular homeostasis and function. Abnormalities in AKAP2 expression or function have been implicated in several diseases, including cardiac hypertrophy and cancer. Understanding the structural characteristics of AKAP2 through recombinant protein studies is vital for elucidating its mechanisms of action and identifying potential therapeutic targets. Recent advances in recombinant DNA technology enable the production of functionally active AKAP2 proteins, facilitating investigations into their interactions with other signaling molecules, and paving the way for novel drug design. By harnessing these recombinant proteins, researchers aim to gain deeper insights into the role of AKAP2 in health and disease, ultimately contributing to the development of targeted therapies for conditions linked to dysregulated PKA signaling.
