Analytical Data
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基因名
TGFBR2/TGF-beta RII
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简介
The TGFBR2/TGF-β RII protein cooperates with TGFBR1 to form dedicated receptors for TGFB1, TGFB2, and TGFB3. It serves as a signal transducer that coordinates diverse physiological and pathological processes, including cell cycle regulation, mesenchymal cell dynamics, wound healing, matrix production, immunosuppression, and carcinogenesis. TGFBR2/TGF-beta RII Protein, Human (sf9, His) is the recombinant human-derived TGFBR2/TGF-beta RII protein, expressed by Sf9 insect cells , with C-His labeled tag.
- Application
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别名
TGFR-2; TGF-beta type II receptor; TGF-beta receptor type 2; TbetaR-II
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种属
Human
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表达系统
Baculovirus
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标签
C-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P37173
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表达区间
T23-Q166
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蛋白长度
Extracellular Domain
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分子量
24 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Transforming growth factor-beta receptor II (TGFBR2) is a crucial component in the TGF-beta signaling pathway, which plays a significant role in various cellular processes, including cell growth, differentiation, and apoptosis. Dysregulation of TGFBR2 has been implicated in multiple diseases, notably cancer and fibrosis, highlighting its importance as a therapeutic target. The study of recombinant TGFBR2 proteins has gained momentum due to their potential applications in drug development and biological research. By producing and characterizing these proteins, researchers aim to understand their structure-function relationships and develop strategies to modulate TGF-beta signaling for clinical benefit. Recombinant TGFBR2 can be used to investigate ligand-receptor interactions, elucidate downstream signaling mechanisms, and screen for small molecule inhibitors. Additionally, given the receptor's role in immune regulation, recombinant forms offer promise for developing novel immunotherapies. Overall, the research surrounding TGFBR2/TGF-beta RII recombinant proteins is pivotal for unraveling the complexities of TGF-beta signaling and exploring their potential in treating diseases associated with its dysregulation.
