Analytical Data
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基因名
PPARD
- Application
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别名
FAAR; NR1C2; NUC1; NUCI; PPARB; PPARd/B; Nuclear Receptor Subfamily 1,Group C,Member 2; Nuclear hormone receptor 1; Peroxisome proliferator-activated receptor beta
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 95% as determined by SDS-PAGE.
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蛋白编号
Q03181
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表达区间
Leu260~Glu426
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分子量
21kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PPARD, or Peroxisome Proliferator-Activated Receptor Delta, is a member of the nuclear receptor superfamily that plays a crucial role in regulating various physiological processes, including lipid metabolism, glucose homeostasis, and inflammation. Research on PPARD has gained significant attention due to its potential implications in metabolic disorders, cardiovascular diseases, and cancer. The protein functions as a transcription factor, modulating gene expression in response to fatty acids and other ligands, thereby influencing metabolic pathways. Studies have shown that PPARD activation can enhance fatty acid oxidation, improve insulin sensitivity, and reduce inflammation, making it an attractive therapeutic target for obesity and type 2 diabetes. Additionally, PPARD is implicated in muscle differentiation and endurance exercise adaptations, underscoring its importance in energy metabolism and physical performance. Advances in recombinant protein technology have facilitated the production of PPARD and its variants, enabling detailed structural and functional studies. These studies aim to elucidate the molecular mechanisms by which PPARD exerts its effects and to identify potential pharmacological agents that can selectively modulate its activity. Understanding the biological role of PPARD and its pathways is essential for developing targeted therapies that harness its beneficial effects while minimizing adverse outcomes, thus offering hope for innovative treatments in metabolic and inflammatory diseases.












