Analytical Data
-
基因名
IL-13Rα1
-
简介
The IL-13R α 1 protein binds to IL13 with low affinity and, when combined with IL4RA, forms a functional IL13 receptor. It also functions together with IL4RA as an alternative accessory protein for IL4 signaling. IL-13R alpha 1 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived IL-13R alpha 1 protein, expressed by HEK293 , with C-hFc labeled tag.
- Application
-
别名
rMuInterleukin-13 receptor subunit alpha-1/IL-13RA1, Fc; Interleukin-13 receptor subunit alpha-1; IL-13RA1; Interleukin-13-binding protein; Novel cytokine receptor 4; NR4; CD213a1
-
种属
Mouse
-
表达系统
HEK293
-
标签
C-hFc
-
纯度
> 90% as determined by SDS-PAGE.
-
蛋白编号
O09030
-
表达区间
A25-T340
-
氨基酸序列
AATEVQPPVTNLSVSVENLCTIIWTWSPPEGASPNCTLRYFSHFDDQQDKKIAPETHRKEELPLDEKICLQVGSQCSANESEKPSPLVKKCISPPEGDPESAVTELKCIWHNLSYMKCSWLPGRNTSPDTHYTLYYWYSSLEKSRQCENIYREGQHIACSFKLTKVEPSFEHQNVQIMVKDNAGKIRPSCKIVSLTSYVKPDPPHIKHLLLKNGALLVQWKNPQNFRSRCLTYEVEVNNTQTDRHNILEVEEDKCQNSESDRNMEGTSCFQLPGVLADAVYTVRVRVKTNKLCFDDNKLWSDWSEAQSIGKEQNST
-
蛋白长度
Partial
-
分子量
80-120 kDa
-
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
-
性状
Freeze-dried powder
-
缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
-
稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
Interleukin-13 receptor subunit alpha-1 (IL-13Rα1) is a key player in the signaling pathways of interleukin-13 (IL-13), a cytokine involved in various biological processes, including immune response and inflammation. Abnormal IL-13 signaling is implicated in a range of diseases, particularly allergic conditions such as asthma, as well as fibrosis in organs like the lungs and liver. The IL-13Rα1 protein is known to form a functional receptor complex with IL-4Rα, enabling the modulation of cellular responses in immune cells. Due to its pivotal role in mediating the effects of IL-13, IL-13Rα1 has emerged as a potential therapeutic target for treating asthma and other IL-13 related disorders. Researchers have focused on developing recombinant IL-13Rα1 proteins to study their structure, function, and interactions with IL-13 and IL-4. These studies are essential for understanding the molecular mechanisms underlying IL-13 signaling and the development of new therapeutic strategies. Additionally, recombinant IL-13Rα1 could serve as a valuable tool in the development of novel antibodies or inhibitors, potentially leading to improved treatments for inflammatory diseases. Overall, the investigation of IL-13Rα1 recombinant proteins holds significant promise for advancing our understanding of IL-13-related pathologies and developing innovative treatment options.
