Analytical Data
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Gene name
OX40 Ligand/TNFSF4 Trimer
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简介
OX40 Ligand/TNFSF4 Protein, a cytokine, binds specifically to TNFRSF4, acting as a potent T-cell co-stimulator for proliferation and cytokine production. Operating as a homotrimer, its engagement enhances immune response by activating and expanding T-cells. The interaction with TNFRSF4 contributes to intricate regulation, crucial for modulating T-cell functions and achieving effective and controlled immune activation. OX40 Ligand/TNFSF4 Protein, Human (HEK293, mFc) is the recombinant human-derived OX40 Ligand/TNFSF4 protein, expressed by HEK293, with C-mFc labeled tag.
- Application
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Alternative Names
OX40L; OX-40L; OX4OL; CD252; TNFSF4; OX40 Ligand; CD134 ligand; CD134L; TXGP1; Glycoprotein Gp34
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Species
Human
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Source
HEK293
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Tag
C-mFc
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P23510-1
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Expression Region
Q51-L183
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Protein Length
Extracellular Domain
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Molecular Weight
53-60 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
OX40 Ligand (TNFSF4) is a member of the tumor necrosis factor (TNF) superfamily and plays a critical role in regulating T cell activation and survival. Its interaction with the OX40 receptor on T cells enhances their proliferation, effector function, and memory formation, making it a potential target for cancer immunotherapy and autoimmune disease treatment. OX40 Ligand is primarily expressed on antigen-presenting cells, including dendritic cells and B cells, which facilitates T cell costimulation in the immune response. Given its importance in immune modulation, recombinant OX40 Ligand/TNFSF4 trimer protein has garnered significant interest in research and therapeutic development. The trimeric form of the protein improves its biological activity and stability, allowing for more effective engagement with its receptor. Studies have demonstrated that OX40 Ligand can enhance anti-tumor immunity by promoting T cell responses and overcoming immune suppression in the tumor microenvironment. Consequently, therapeutic strategies aimed at augmenting OX40 signaling hold promise for enhancing the efficacy of cancer vaccines and immune checkpoint inhibitors. Furthermore, understanding the structural and functional characteristics of the recombinant OX40 Ligand/TNFSF4 trimer can provide insights into the design of novel immunotherapeutics. Overall, ongoing research focuses on harnessing the potential of OX40 Ligand to boost immune responses, with the goal of developing new treatment modalities for various cancers and autoimmune conditions.
