Analytical Data
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基因名
AMCase/CHIA
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简介
AMCase/CHIA protein is an enzyme that degrades chitin and chitotriose and is involved in defense against nematodes, fungi, and pathogens.It plays a role in Th2 immune responses, in response to IL-13, and in the induction of inflammation.AMCase/CHIA Protein, Human (HEK293, His) is the recombinant human-derived AMCase/CHIA protein, expressed by HEK293 , with C-His labeled tag.
- Application
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别名
Acidic mammalian chitinase; AMCase; CHIA; CHIT2; EC 3.2.1.14; Chia1; YNL
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种属
Human
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表达系统
HEK293
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标签
C-8*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9BZP6
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表达区间
Y22-A476
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蛋白长度
Full Length of Mature Protein
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分子量
55-60 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
AMCase (acidic mammalian chitinase) and CHIA (chitinase 3-like 1) are significant proteins belonging to the glycoside hydrolase family, which play vital roles in chitin degradation and immune responses. AMCase was first identified in mammalian systems where it is predominantly expressed in the lungs and is implicated in various biological processes, including allergy and asthma. Its ability to break down chitin, a structural polysaccharide found in the exoskeletons of insects and the cell walls of fungi, positions it as a potential therapeutic target for diseases associated with chitin-containing pathogens. CHIA, on the other hand, is a member of the chitinase-like protein family and is involved in modulating inflammatory responses and tissue repair. Research has shown that CHIA might be linked to obesity and metabolic disorders. The recombinant expression of AMCase and CHIA allows for in-depth studies of their structure-function relationships and biological activities. This provides essential insights into their roles in health and disease, as well as potential applications in biotechnology and pharmacology. The successful production of these recombinant proteins can facilitate the development of novel therapeutics that harness their chitinase activities, promoting further exploration of their therapeutic potential in treating allergic diseases, infections, and metabolic disorders.
