Analytical Data
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基因名
IL-34
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简介
IL-34 protein is an important cytokine that promotes the proliferation, survival, and differentiation of monocytes and macrophages. It plays a key role in innate immune responses and inflammatory processes by promoting the release of pro-inflammatory chemokines. IL-34 Protein, Human (CHO, His) is the recombinant human-derived IL-34 protein, expressed by CHO , with C-His labeled tag.
- Application
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别名
Interleukin-34; IL-34; C16orf77
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种属
Human
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表达系统
CHO
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标签
C-His
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纯度
> 90% as determined by SDS-PAGE.
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蛋白编号
Q6ZMJ4
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表达区间
N21-P242
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氨基酸序列
NEPLEMWPLTQNEECTVTGFLRDKLQYRSRLQYMKHYFPINYKISVPYEGVFRIANVTRLQRAQVSERELRYLWVLVSLSATESVQDVLLEGHPSWKYLQEVQTLLLNVQQGLTDVEVSPKVESVLSLLNAPGPNLKLVRPKALLDNCFRVMELLYCSCCKQSSVLNWQDCEVPSPQSCSPEPSLQYAATQLYPPPPWSPSSPPHSTGSVRPVRAQGEGLLP
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蛋白长度
Full Length of Isoform-1 Mature Protein
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分子量
26.7 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
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Protein Description
IL-34 (Interleukin-34) is a cytokine that plays a crucial role in the regulation of immune responses, particularly in the differentiation and survival of macrophages. Discovered in 2008, its unique ability to bind to the colony-stimulating factor 1 receptor (CSF1R) distinguishes it from other monocyte/macrophage growth factors. Research into IL-34 has gained momentum due to its implications in various pathological conditions, including chronic inflammatory diseases, autoimmune disorders, and cancer. The recombinant protein version of IL-34 is a valuable tool for studying its biological functions and mechanisms of action. It can be used to assess the effects of IL-34 on macrophage polarization, migration, and cytokine production, providing insights into its role in both health and disease. Moreover, due to its involvement in the tumor microenvironment, IL-34 is being investigated as a potential therapeutic target for cancer treatment. Understanding the structure, signaling pathways, and functional properties of recombinant IL-34 can lead to the development of novel therapeutic strategies aimed at modulating immune responses in various diseases.
