Analytical Data
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Gene name
AIM2
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简介
AIM2 protein is a key sensor in the AIM2 inflammasome, which can activate the inflammasome in response to cytoplasmic dsDNA, thereby inducing pyroptosis. This complex is triggered by pathogens or injury signals and plays a critical role in innate immunity and inflammation. AIM2 Protein, Human is the recombinant human-derived AIM2 protein, expressed by E. coli , with tag free.
- Application
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Alternative Names
AIM2; Interferon-inducible protein AIM2; Absent in melanoma 2
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Species
Human
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Source
E. coli
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Tag
Tag Free
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O14862
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Expression Region
S144-T343
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Protein Length
Partial
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
AIM2 (Absent in Melanoma 2) is a cytosolic DNA sensor that plays a crucial role in the innate immune response by detecting foreign DNA in the cytoplasm, such as that from viruses and bacteria. Its activation leads to an inflammatory response through the formation of inflammasomes, which are multi-protein complexes that activate caspase-1 and promote the secretion of pro-inflammatory cytokines like IL-1β and IL-18. Research into AIM2 has gained momentum due to its implications in various diseases, including autoimmune disorders, cancer, and inflammatory diseases. Recombinant AIM2 protein studies are essential for understanding the structural and functional mechanisms of this sensor, as well as for exploring its potential as a therapeutic target. The ability to produce AIM2 as a recombinant protein allows for detailed biochemical studies, including its interactions with nucleic acids, other immune signaling molecules, and cellular pathways. Furthermore, characterizing AIM2’s role in inflammation and pathogen recognition can provide insights into how the immune system distinguishes between self and non-self DNA, enhancing our comprehension of dysregulation in immune responses. Hence, the research on AIM2 recombinant protein not only contributes to basic immunology but also holds promise for developing novel therapeutic strategies against a range of inflammatory and infectious diseases.
