Analytical Data
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Gene name
CD94
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简介
The NKG2A protein is an important immunosuppressive receptor that forms a complex with KLRD1 on lymphocyte subsets for self-non-self discrimination. It recognizes HLA-E loaded with self-peptides, monitors MHC class I expression in healthy cells, and promotes self-tolerance. NKG2A-CD94 Heterodimer Protein, Human (Biotinylated, HEK293, His-Avi) is a recombinant protein dimer complex containing human-derived NKG2A-CD94 Heterodimer protein, expressed by HEK293 , with N-His, N-Avi labeled tag. NKG2A-CD94 Heterodimer Protein, Human (Biotinylated, HEK293, His-Avi), has molecular weight of 33-48 kDa.
- Application
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Alternative Names
CD159a; NKG2A; NKG2-A; CD94; NKG2A&CD94
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Species
Human
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Source
HEK293
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Tag
N-Avi;N-8*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P26715 (R100-L233)&Q13241
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Expression Region
P26715 (R100-L233)&Q13241 (S34-I179)
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Molecular Weight
33-48 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CD94 is a type II transmembrane protein predominantly expressed on natural killer (NK) cells and certain T cells, playing a pivotal role in the immune response. It forms heterodimers with NKG2 receptors, which are critical for the recognition of stressed or infected cells. Research has shown that the CD94/NKG2 complex is essential for the regulation of NK cell activity, particularly in distinguishing between healthy and abnormal cells. The study of CD94 recombinant proteins has gained prominence as these proteins serve as valuable tools for understanding the molecular mechanisms underlying NK cell activation and inhibition. Furthermore, CD94 has been implicated in various diseases, including viral infections and cancers, making it a target for therapeutic interventions. By characterizing CD94 recombinant proteins, researchers aim to elucidate their functional roles in immune responses and to explore their potential applications in immunotherapy and vaccine development. Understanding the structural and functional nuances of CD94 will provide insights into its role in immune regulation and potentially lead to novel strategies for enhancing anti-tumor immunity or mitigating autoimmune diseases. Overall, the investigation of CD94 recombinant proteins represents a significant area of research with implications for both basic immunology and clinical applications.
