Analytical Data
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Gene name
IL-24R beta
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简介
IL-20R beta Protein (IL20RB) is the beta subunit of IL-20 receptor, forms functional heterodimers with different subunit protein and involves in STAT3 activation pathway[1]. The IL-20RA/IL-20RB dimer is a receptor for IL-19, IL-20 and IL-24. The IL-22RA1/IL-20RB dimer is a receptor for IL-20 and IL-24[2]. IL-20R beta Protein is consists of 311 amino acids (M1-S311) with a transmembrane domain (234-254 a.a.). IL-20R beta Protein, Human (sf9, His) is produced in Sf9 insect cells with a C-Terminal His-tag.
- Application
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Alternative Names
Interleukin-20 receptor subunit beta; IL-20R-beta; IL-20RB; FNDC6; IL-20R2; DIRS1
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Species
Human
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Source
Baculovirus
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Tag
C-His
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Purity
> 90% as determined by SDS-PAGE.
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Uniprot
Q6UXL0
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Expression Region
D30-A230
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Protein Length
Extracellular Domain
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Molecular Weight
23.9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
IL-24R beta, a critical component of the interleukin-24 receptor complex, plays a significant role in mediating the functions of IL-24, a cytokine known for its pro-apoptotic and anti-tumor effects. Understanding the structure and function of IL-24R beta is essential for elucidating the mechanisms by which IL-24 exerts its biological activities, particularly in cancer therapy. Research has shown that IL-24 can induce apoptosis in various cancer cell types while sparing normal cells, positioning it as a promising agent in targeted cancer treatments. However, the specific signaling pathways and interactions involving IL-24R beta remain poorly characterized. Recent studies involving the recombinant expression of IL-24R beta have aimed to provide insights into its role in receptor signaling and the therapeutic potential of IL-24-based interventions. By generating and assessing IL-24R beta recombinant proteins, researchers aim to facilitate the development of novel therapeutic strategies that leverage the unique properties of this cytokine and its receptor, potentially leading to more effective treatments for cancer and other diseases associated with dysregulated IL-24 signaling. This ongoing research not only enhances our understanding of cytokine receptor interactions but also opens avenues for innovative therapeutic applications in oncology.
