Analytical Data
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Gene name
IL-25R beta
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简介
IL-20R beta Protein (IL20RB) is the beta subunit of IL-20 receptor, forms functional heterodimers with different subunit protein and involves in STAT3 activation pathway[1]. The IL-20RA/IL-20RB dimer is a receptor for IL-19, IL-20 and IL-24. The IL-22RA1/IL-20RB dimer is a receptor for IL-20 and IL-24[2]. IL-20R beta Protein is consists of 308 amino acids (M1-T308) with a transmembrane domain (226-249 a.a.). IL-20R beta Protein, Rat (HEK293, His) is produced in HEK293 cells with a C-Terminal His-tag.
- Application
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Alternative Names
Interleukin-20 receptor subunit beta; IL-20R-beta; IL-20RB; FNDC6; IL-20R2; DIRS1
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Species
Cynomolgus
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Source
HEK293
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Tag
C-hFc
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Purity
> 90% as determined by SDS-PAGE.
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Uniprot
G7P041
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Expression Region
D30-A230
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Protein Length
Partial
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Molecular Weight
49.2 kDa.
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Interleukin-25 receptor (IL-25R), also known as IL-17RB, plays a crucial role in the immune response, particularly in the activation and differentiation of T-helper type 2 (Th2) cells. Its interaction with IL-25 (also known as IL-17E) promotes the secretion of additional cytokines such as IL-4, IL-5, and IL-13, which are pivotal in mediating allergic responses and asthma pathogenesis. Research on IL-25R beta recombinant protein has gained momentum due to its potential therapeutic implications in treating various allergic diseases, including asthma and other Th2-mediated conditions. By understanding the structure and function of IL-25R beta, scientists aim to develop targeted therapies that can modulate the immune response more effectively. With the increasing prevalence of allergic diseases worldwide, the need for novel and effective treatments has become more urgent. Thus, characterizing the IL-25R beta recombinant protein facilitates not only the understanding of its signaling pathways and biological functions but also enables the exploration of its utility as a biomarker or therapeutic target in allergic inflammation and other related disorders. This research could lead to innovative strategies for combating the increasing burden of allergic diseases and improving patient outcomes.
