Analytical Data
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Gene name
IL-37
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简介
IL-37 protein is an important immunoregulatory cytokine that suppresses innate inflammation and immune responses and reduces excessive inflammation.It signals intracellularly through nuclear translocation of SMAD3 and extracellularly through binding to its receptors, consisting of IL18R1 and IL18RAP.Animal-Free IL-37 Protein, Human (His) is the recombinant human-derived animal-FreeIL-37 protein, expressed by E.coli , with C-His labeled tag.This product is for cell culture use only.
- Application
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Species
Human
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Source
E. coli
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Tag
C-6*His
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Purity
> 90% as determined by SDS-PAGE.
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Uniprot
Q9NZH6
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Expression Region
K53-D218
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Protein Length
Partial
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Molecular Weight
22 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
Interleukin-37 (IL-37) is a member of the IL-1 family of cytokines, known for its crucial role in modulating the immune response and inflammation. Discovered in 2000, IL-37 is characterized by its ability to inhibit pro-inflammatory cytokine production and promote an anti-inflammatory environment. This unique function positions IL-37 as a potential therapeutic target for various inflammatory and autoimmune diseases, such as rheumatoid arthritis, chronic inflammatory bowel diseases, and cardiovascular disorders. Research has shown that IL-37 can suppress the activation of NF-κB and MAPK signaling pathways, contributing to its anti-inflammatory effects. Given its significance in immune regulation, recombinant IL-37 protein has gained attention in experimental studies aimed at elucidating its underlying mechanisms. Recombinant production techniques allow for the generation of biologically active IL-37, facilitating investigations into its protective roles in inflammatory diseases and its potential to enhance therapeutic strategies. Furthermore, preclinical models have demonstrated that administering IL-37 can alleviate symptoms associated with inflammation, making it a promising candidate for future clinical applications. Overall, the study of recombinant IL-37 protein is vital for advancing our understanding of immune modulation and exploring novel treatments for inflammatory conditions.
