Analytical Data
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Gene name
CACNA2D1
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简介
The CACNA2D1 protein, particularly its α-2/δ subunit, plays a key role in regulating calcium current density and activation/deactivation kinetics of voltage-dependent calcium channels. It contributes to excitation-contraction coupling, coordinating cellular processes. CACNA2D1 Protein, Human (His-SUMO) is the recombinant human-derived CACNA2D1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
- Application
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Species
Human
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Source
E. coli
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Tag
N-6*His;N-SUMO
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P54289
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Expression Region
Q528-N668
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Protein Length
Partial
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
CACNA2D1 encodes the alpha-2/delta-1 subunit of voltage-gated calcium channels, which are crucial for various physiological processes, including muscle contraction, neurotransmitter release, and neuronal excitability. Abnormalities in calcium channel function have been linked to a range of pathological conditions, including epilepsy, cardiac arrhythmias, and certain types of cancer. The alpha-2/delta-1 subunit plays a pivotal role in modulating calcium channel activity and trafficking, making it an attractive target for research and therapeutic intervention. Recent studies have focused on the structural and functional characterization of CACNA2D1 recombinant proteins to elucidate their role in calcium signaling pathways and their potential implications in disease. Understanding the mechanisms underlying CACNA2D1 function could provide insights into novel treatment strategies for calcium channel-related disorders and facilitate the development of pharmacological agents that target this subunit specifically. As the research community continues to explore the multifaceted roles of calcium signaling in health and disease, CACNA2D1 remains a critical focus for advancing our knowledge of calcium dynamics and its therapeutic potentials.
