Analytical Data
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基因名
GNAO1
- Application
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别名
Gna0, Gnao
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种属
Mouse
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表达系统
Yeast
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标签
Tag Free
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P18872
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表达区间
2-354aa
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分子量
40 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GNAO1 is a gene that encodes a guanine nucleotide-binding protein, belonging to the Gαo family of G proteins, which play a crucial role in neurotransmitter signaling pathways. Mutations in the GNAO1 gene have been linked to a spectrum of neurological disorders, including developmental delay, seizures, and movement disorders, primarily in infants and young children. Understanding the functional implications of GNAO1 mutations is essential for elucidating their pathological roles and developing targeted therapies. The study of recombinant GNAO1 proteins allows researchers to investigate the effects of specific mutations on protein function, such as GTPase activity and interaction with downstream effectors. This research can contribute to a better understanding of the mechanisms underlying GNAO1-related disorders and aid in the discovery of potential therapeutic strategies. Additionally, recombinant proteins can serve as valuable tools for drug screening and testing, providing insights into the efficacy of compounds that may modulate G protein signaling pathways. Overall, the exploration of GNAO1 recombinant proteins is vital for advancing our knowledge of its biological significance and the impact of genetic variations on human health.
