Analytical Data
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Gene name
RBBP4
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简介
The RBBP4 protein is a core histone-binding subunit that directs chromatin regulators and histone deacetylases to their substrates and participates in chromatin metabolism.RBBP4 Protein, Mouse (sf9, His) is the recombinant mouse-derived RBBP4 protein, expressed by Sf9 insect cells , with N-His labeled tag.
- Application
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Alternative Names
Histone-binding protein RBBP4; CAF-I p48; RBBP-4; RBAP48
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Species
Mouse
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Source
Baculovirus
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q60972
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Expression Region
M1-S425
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Protein Length
Full Length
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RBBP4, or Retinoblastoma Binding Protein 4, is a nuclear protein that plays a crucial role in various cellular processes, including cell cycle regulation, chromatin remodeling, and gene expression. It is known to interact with the retinoblastoma tumor suppressor protein, modulating its function and contributing to cell proliferation and differentiation. Research on RBBP4 has gained considerable attention due to its implications in cancer biology, particularly its involvement in tumor progression and the regulation of oncogenes and tumor suppressor genes. The reconstitution and characterization of RBBP4 recombinant protein are essential for understanding its structural and functional properties, which could reveal insights into the molecular mechanisms underlying cell cycle dysregulation in cancer. Additionally, studying the interactions of RBBP4 with other proteins and chromatin components can provide a better understanding of its role in epigenetic regulation. This research may also contribute to the development of targeted therapies for cancers associated with aberrant RBBP4 expression or function. Given the increasing evidence linking RBBP4 to various diseases, including several types of cancer, further investigation into its recombinant form is vital for elucidating its biological activities and potential as a therapeutic target.
