Analytical Data
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基因名
Centrin-2
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简介
Centrin-2 protein plays a critical role in microtubule-organized centromere structure, directing centriole duplication, spindle formation, and regulation of cytokinesis. It ensures genome stability by interacting with CALM1 and CCP110. Centrin-2 Protein, Human (HEK293, His) is the recombinant human-derived Centrin-2 protein, expressed by HEK293 , with C-His labeled tag.
- Application
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别名
Centrin-2; Caltractin isoform 1; CETN2; CALT; CEN2
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种属
Human
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表达系统
HEK293
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标签
C-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P41208
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表达区间
M1-Y172
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蛋白长度
Full Length
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Centrin-2 is a crucial protein belonging to the centrin family, which plays a pivotal role in various cellular processes, including cell cycle regulation, ciliary function, and signal transduction. It is primarily expressed in ciliated cells and is implicated in the formation and maintenance of the centrosome and the basal bodies of cilia. Research into Centrin-2 has gained significance due to its involvement in several human diseases, particularly those related to reproductive health and ciliopathies, which are disorders arising from defective cilia function. Understanding its structure and function is essential for elucidating the mechanisms underlying these conditions. Recent advancements in recombinant protein technology have facilitated the production of Centrin-2 in various expression systems, allowing for in-depth biochemical characterization and structural studies. These studies aim to uncover the protein's interactions with other cellular components and its involvement in cellular signaling pathways. Furthermore, recombinant Centrin-2 is being explored for its potential role as a therapeutic target, given its pivotal functions in cell division and disease pathology. Investigating the properties and dynamics of Centrin-2 not only enhances our understanding of cellular biology but also opens avenues for developing novel strategies in treating diseases associated with ciliary dysfunction. As such, the study of Centrin-2 and its recombinant forms stands at the forefront of molecular biology research, with implications that extend to medical science and therapeutic development.
