Analytical Data
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Gene name
ULBP4/RAET1E
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简介
ULBP4/RAET1E Protein crucially activates natural killer cell cytotoxicity by binding to and activating the KLRK1/NKG2D receptor. This interaction mediates cytotoxic responses, contributing to receptor activation and facilitating the recognition and targeting of marked cells for elimination. ULBP4/RAET1E's engagement with KLRK1/NKG2D underscores its significance in immune response regulation and natural killer cell activity modulation. ULBP4/RAET1E Protein, Human (HEK293, Fc) is the recombinant human-derived ULBP4/RAET1E protein, expressed by HEK293 , with C-hFc labeled tag.
- Application
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Alternative Names
Retinoic acid early transcript 1E; NKG2D ligand 4; LETAL; N2DL4
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Species
Human
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Source
HEK293
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Tag
C-hFc
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8TD07-1
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Expression Region
H31-D225
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Protein Length
Extracellular Domain
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Molecular Weight
49.1 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ULBP4, also known as RAET1E, is a member of the ULBP (UL16-binding protein) family, which plays a significant role in immune regulation, particularly in the context of natural killer (NK) cell activity. These proteins act as ligands for NKG2D, an activating receptor expressed on NK cells and certain T cells, facilitating the recognition and elimination of stressed, infected, or transformed cells. ULBP4/RAET1E is particularly interesting because it is involved in the modulation of immune responses in various pathological conditions, including cancer, viral infections, and autoimmune diseases. Studies have shown that ULBP4/RAET1E can influence the tumor microenvironment and affect NK cell-mediated cytotoxicity, making it a potential target for cancer immunotherapy. Understanding the molecular mechanisms underlying ULBP4/RAET1E function and its interactions with immune cells can provide insights into developing novel therapeutic strategies aimed at enhancing anti-tumor immunity. Moreover, characterizing recombinant ULBP4/RAET1E proteins can aid in elucidating their structure-function relationships and pave the way for the design of innovative therapeutic agents that exploit the natural immune response. This research is critical for advancing knowledge in immunology and has potential implications for improving treatments for various malignancies and infections.
