Analytical Data
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Gene name
VSNL1
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简介
VSNL1 mediates rhodopsin phosphorylation inhibition in vitro and its activity is dependent on calcium levels. This implies that VSNL1 plays a role in regulating rhodopsin phosphorylation dynamics, which is critical for photoreceptor cell signaling. VSNL1 Protein, Human is the recombinant human-derived VSNL1 protein, expressed by E. coli , with tag free.
- Application
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Alternative Names
Visinin-like protein 1; VILIP; VLP-1; Hippocalcin-like protein 3; HLP3; VSNL1; VISL1
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Species
Human
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Source
E. coli
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Tag
Tag Free
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P62760
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Expression Region
G2-K191
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Protein Length
Full Length of Mature Protein
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Molecular Weight
19 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
VSNL1, also known as visual system nexin 1, is a multifunctional protein primarily expressed in the retina, where it plays a crucial role in regulating synaptic transmission and signal processing in photoreceptor cells. Recent studies have highlighted its involvement in various neurological disorders and retinal diseases, suggesting that VSNL1 may have potential as a therapeutic target. The recombinant form of VSNL1 allows researchers to investigate its biochemical properties and functional implications in cellular signaling pathways. By understanding the molecular mechanisms through which VSNL1 operates, scientists aim to uncover its role in neurodegeneration and synaptic dysfunction. This research is particularly relevant in the context of developing novel therapeutic strategies for conditions like retinitis pigmentosa and age-related macular degeneration. Moreover, recombinant VSNL1 can be utilized in pharmacological assays to screen for potential drug candidates that modulate its activity, thereby paving the way for innovative treatments. Overall, the investigation of VSNL1 and its recombinant protein holds significant promise for advancing our knowledge of retinal biology and addressing unmet medical needs in vision-related disorders.
