Analytical Data
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Gene name
XRCC6
- Application
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Alternative Names
G22P1
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Species
Human
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Source
E. coli
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Tag
C-Flag
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P12956-1
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Expression Region
M1-D609
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Protein Length
Full Length of Isoform-1
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Molecular Weight
70.9 KDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
XRCC6, also known as the Ku70/80 heterodimer, plays a crucial role in the DNA damage repair process, specifically in the non-homologous end joining (NHEJ) pathway. This protein complex is essential for maintaining genomic stability, as it is involved in recognizing and binding to DNA double-strand breaks, facilitating their repair, and ultimately preventing cellular malfunctions that could lead to cancer and other genetic disorders. Research on XRCC6 has intensified in recent years due to its implications in cancer biology, as mutations or dysregulation of XRCC6 can lead to increased susceptibility to DNA damage and tumorigenesis. Additionally, XRCC6 has been implicated in various cellular processes beyond DNA repair, including V(D)J recombination and telomere maintenance, highlighting its multifaceted role in cellular health. Understanding the molecular mechanisms governing XRCC6 function and its interactions with other proteins involved in DNA repair and signaling pathways can provide insights into potential therapeutic targets for cancer treatment and strategies for enhancing genome integrity. Consequently, the study of XRCC6 recombinant protein has become a focal point for researchers aiming to elucidate its biochemical properties and develop novel approaches to intervene in diseases associated with impaired DNA repair mechanisms.
