Analytical Data
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Gene name
TCEB3
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简介
TCEB3, also known as SIII, acts as a key transcription elongation factor that promotes RNA polymerase II progression beyond the blocking site. It interacts with SIII regulatory subunits B and C to form the elongin BC complex, which significantly enhances the transcriptional activity of subunit A. TCEB3 Protein, Human (sf9) is the recombinant human-derived TCEB3 protein, expressed by sf9 insect cells , with tag free.
- Application
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Alternative Names
ELOA (TCEB3); Elongin-A; EloA; Elongin 110 kDa subunit; RNA polymerase II transcription factor SIII subunit A1; SIII p110; Transcription elongation factor B polypeptide 3
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Species
Human
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Source
Baculovirus
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Tag
Tag Free
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q14241
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Expression Region
H2-R798
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Protein Length
Partial
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TCEB3, or T-complex protein 1 subunit beta 3, is a key component of the eukaryotic translation elongation factor complex, playing a crucial role in the regulation of protein synthesis and cellular stress responses. Research into TCEB3 and its recombinant proteins has gained significant attention due to its involvement in various biological processes and diseases, including cancer and neurodegenerative disorders. The study of TCEB3 provides insights into the fundamental mechanisms of translation and has implications for therapeutic interventions. Recombinant TCEB3 proteins are essential for elucidating its function, understanding the molecular interactions within the translation machinery, and exploring its potential as a biomarker for cellular stress. Advances in recombinant protein technologies have facilitated the production and characterization of TCEB3, enabling researchers to investigate its structure-function relationships and develop strategies to modulate its activity. This research is particularly relevant in the context of drug discovery, where targeting TCEB3 pathways may offer new avenues for treating diseases associated with translation dysregulation. Consequently, the exploration of TCEB3 as a recombinant protein serves as a vital area of study that bridges molecular biology and therapeutic development, highlighting its importance in both basic and applied sciences.
