Analytical Data
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基因名
OTULIN
- Application
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别名
FAM105B
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种属
Human
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表达系统
E. coli
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标签
His;GST
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q96BN8
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表达区间
M1-L352
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蛋白长度
Full Length
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
OTULIN, a member of the A20 protein family, functions as a deubiquitinating enzyme that plays a critical role in regulating immune responses and maintaining cellular homeostasis. Given its involvement in the removal of ubiquitin chains from modified proteins, OTULIN is essential for controlling inflammation and apoptosis pathways. Research has shown that mutations or dysregulation of OTULIN are linked to various autoimmune diseases and conditions characterized by chronic inflammation, underscoring its importance in human health. Recent studies have aimed to elucidate the structural and functional aspects of OTULIN, paving the way for potential therapeutic strategies targeting its pathways to mitigate autoimmune disorders and improve patient outcomes. As such, the recombinant production of OTULIN has become a focal point for understanding its biological mechanisms and developing targeted interventions. This research not only enhances our fundamental knowledge of ubiquitination processes but also holds promise for innovative treatments in immunological diseases.
