Analytical Data
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基因名
NRG1-beta 2
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简介
HRG1-β1 belongs to a family of structurally-related polypeptide growth factors derived from alternatively spliced genes, induces Fn14 expression in MCF7 cells. NRG1-beta 2 Protein, Human is the recombinant human-derived NRG1-beta 2 protein, expressed by E. coli , with tag free.
- Application
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生物活性
The ED50 is <50> 2.0×104 units/mg. Measured in a serum-free cell proliferation assay using MCF-7 human breast cancer cells. The ED50 for this effect is 33.72 ng/mL. corresponding to a specific activity is 2.96×104 units/mg.
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别名
NRG-1 EGF-like domain beta 2; Beta2; Neuregulin-1 beta 2
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种属
Human
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表达系统
E. coli
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标签
Tag Free
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纯度
Greater than 95% as determined by reducing SDS-PAGE.
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蛋白编号
Q02297-7 (S177-Q237)
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表达区间
S23-Q83
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蛋白长度
Partial
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分子量
8 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
NRG1 (neuregulin-1) is a crucial signaling molecule involved in various biological processes, including neural development, cardiac function, and synaptic plasticity. Among its several isoforms, NRG1-beta 2 has garnered significant interest due to its role in the modulation of neurotransmitter release and its potential implications in neurological disorders such as schizophrenia and Alzheimer's disease. Research has shown that NRG1-beta 2 interacts with the ErbB receptor family, influencing synaptic function and neurodevelopmental processes. Advances in recombinant protein technology have enabled the production of NRG1-beta 2 for in-depth functional studies and therapeutic applications. By generating and characterizing NRG1-beta 2 recombinant protein, researchers aim to elucidate its molecular mechanism of action, assess its impact on neuronal signaling pathways, and explore its potential as a biomarker or therapeutic target for various neuropsychiatric conditions. The ongoing research on NRG1-beta 2 not only enhances our understanding of neurobiological processes but also opens new avenues for targeted pharmacological interventions. As such, the investigation of NRG1-beta 2 serves as a promising frontier in neuroscience research, with implications for both basic science and clinical applications.
