Analytical Data
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基因名
CDK2-CCNO
- Application
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别名
CDKN2; p33(CDK2); Cell division protein kinase 2; p33 protein kinase
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种属
Mouse
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表达系统
E. coli
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标签
N- His & GST
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纯度
Greater than 95% as determined by SDS-PAGE.
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蛋白编号
P97377
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表达区间
Ala93~His211
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分子量
43kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CDK2 (Cyclin-Dependent Kinase 2) is a crucial enzyme that plays a significant role in cell cycle regulation, particularly during the transition from the G1 phase to the S phase. It is activated by binding to specific cyclins, with cyclin E and cyclin A being the most notable partners. CCNO (Cyclin O) is an atypical cyclin that has been implicated in various cellular processes, including cell proliferation and response to DNA damage. Recent studies suggest that the CDK2-CCNO complex may have distinct functions compared to other CDK-cyclin complexes, particularly in the regulation of the cell cycle and potential involvement in oncogenic pathways. The reconstitution and functional characterization of the CDK2-CCNO fusion protein provide insights into the unique biochemical properties and cellular roles of this complex. Understanding the mechanisms by which CDK2-CCNO modulates cell cycle progression could unveil new therapeutic targets for cancer treatment, especially in tumors exhibiting dysregulation of cell cycle machinery. The ongoing research aims to elucidate the structural dynamics, regulatory mechanisms, and functional implications of the CDK2-CCNO interaction, highlighting its importance in maintaining cellular homeostasis and its potential role in cancer biology.
