Analytical Data
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Gene name
TMX1
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简介
TMX1 Protein is a member of the protein disulfide isomerase (PDI) family and is a transmembrane thiol isomerase. TMX1 Protein can participate in various redox reactions, reversibly oxidizes to disulfide through its active center thiol, and catalyzes the thiol-disulfide exchange reaction. In addition, TMX1 Protein negatively regulates the activation of αibβ3 integrin and platelet aggregation outside the cell. TMX1 Protein, Human (HEK293, Fc) is the recombinant human-derived TMX1 protein, expressed by HEK293 , with C-mFc labeled tag.
- Application
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Alternative Names
Thioredoxin-related transmembrane protein 1; TMX; TXNDC; TXNDC1
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Species
Human
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Source
HEK293
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Tag
C-mFc
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
AAH36460
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Expression Region
R27-S180
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Protein Length
Partial
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Molecular Weight
45-50 kDa.
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TMX1 (Thioredoxin-related transmembrane protein 1) is a member of the thioredoxin family, which plays a significant role in cellular redox regulation and protein folding. Research into TMX1 has gained momentum due to its implication in various physiological and pathological processes, including apoptosis, oxidative stress response, and cancer progression. It is primarily located in the endoplasmic reticulum (ER) and is involved in maintaining ER homeostasis, facilitating the folding of nascent proteins, and mediating the cellular response to stress. Furthermore, TMX1 has been linked to the modulation of immune responses and is thought to influence the sensitivity of cancer cells to therapeutic agents. Given its critical biological functions, TMX1 is a promising target for therapeutic interventions in diseases characterized by dysregulated redox balance and protein misfolding. The production of recombinant TMX1 protein allows for detailed biochemical and biophysical characterization, paving the way for studies aimed at understanding its specific mechanisms of action and potential as a biomarker or therapeutic target in diseases such as cancer and neurodegenerative disorders. Thus, ongoing research into TMX1 reaffirms its significance in both basic and translational biomedical science.
