Analytical Data
-
Gene name
VIPR2
-
简介
VIPR2 protein, serving as a receptor for Vasoactive Intestinal Peptide (VIP) and Pituitary Adenylate Cyclase-Activating Peptide (PACAP-38 and -27), activates adenylyl cyclase and can also couple with phospholipase C. Its versatile signaling pathways emphasize its pivotal role in transducing signals from VIP and PACAP, participating in cellular processes regulated by cyclic AMP and phosphoinositide signaling cascades. VIPR2 Protein, Human (HEK293, Fc) is the recombinant human-derived VIPR2 protein, expressed by HEK293 , with C-mFc labeled tag.
- Application
-
Alternative Names
Vasoactive intestinal polypeptide receptor 2; VIP-R-2; PACAP-R3; VPAC2; VIPR2
-
Species
Human
-
Source
HEK293
-
Tag
C-mFc
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
P41587
-
Expression Region
E24-V126
-
Protein Length
Partial
-
Molecular Weight
45-60 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
VIPR2 (Vasoactive Intestinal Peptide Receptor 2) is a member of the G-protein coupled receptor family and plays a crucial role in various physiological processes, including neurotransmission and immune response regulation. Research has shown that VIP and its receptors, including VIPR2, are involved in neuroprotection, modulation of circadian rhythms, and various neurodegenerative diseases. Understanding the structure and function of VIPR2 is vital for the development of therapeutic strategies targeting disorders related to its dysregulation, such as anxiety, depression, and gastrointestinal diseases. The production of recombinant VIPR2 protein allows for in-depth studies of its signaling pathways, ligand interactions, and potential pharmacological inhibitors. By generating a recombinant form of VIPR2, researchers can dissect the receptor's role in cellular processes and contribute to the design of drugs that could modulate its activity, thereby offering new avenues for treatment options in related pathologies. The continuous exploration of VIPR2's molecular mechanisms also sheds light on the broader implications of vasoactive intestinal peptide signaling in health and disease.
