Analytical Data
-
基因名
MAGOH
-
简介
MAGOH is an important spliceosome component that cooperates with MAGOHB to form the exon junction complex (EJC), which is central to pre-mRNA splicing and nonsense-mediated decay (NMD). EJC affects mRNA metabolism, marks exon-exon junctions, and affects processes such as mRNA export, localization, translation, and NMD. MAGOH Protein, Human (His) is the recombinant human-derived MAGOH protein, expressed by E. coli , with C-6*His labeled tag.
- Application
-
别名
Protein mago nashi homolog; MAGOH; MAGOHA
-
种属
Human
-
表达系统
E. coli
-
标签
C-6*His
-
纯度
Greater than 95% as determined by SDS-PAGE.
-
蛋白编号
P61326-1
-
表达区间
M1-I146
-
蛋白长度
Full Length of Isoform-1
-
分子量
17 kDa.
-
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
-
性状
Freeze-dried powder
-
缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
-
稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
MAGOH, a key component of the exon junction complex (EJC), plays a crucial role in RNA metabolism, including mRNA stability, splicing, and translation regulation. This protein interacts with various RNA-binding proteins and is implicated in several cellular processes, such as gene expression regulation and response to cellular stress. Recent studies have highlighted the importance of MAGOH in cancer biology, demonstrating its involvement in tumor progression and metastasis. Additionally, MAGOH has been linked to the modulation of RNA processing and surveillance mechanisms, suggesting that its dysregulation can lead to various diseases, including neurodegenerative disorders. The exploration of MAGOH's structure and function through recombinant protein studies is therefore critical for understanding its biological roles and potential as a therapeutic target. Researchers aim to investigate the biochemical properties of MAGOH, its interactions with other EJC components, and its influence on mRNA fate, which can provide insights into new avenues for treatment in diseases where MAGOH is deregulated. By producing and characterizing recombinant MAGOH, scientists hope to elucidate its mechanisms of action and develop strategies for modulating its function in a clinical context.
