Analytical Data
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基因名
Osteomodulin
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简介
Osteomodulin protein likely contributes to biomineralization processes, influencing the formation and regulation of mineralized tissues.It binds to osteoblasts via the alpha(V)beta(3)-integrin, indicating involvement in cell adhesion and interactions with the extracellular matrix.The specific binding to the alpha(V)beta(3)-integrin suggests its potential role in mediating cellular processes associated with integrin signaling.Osteomodulin Protein, Mouse (HEK293, His) is the recombinant mouse-derived Osteomodulin protein, expressed by HEK293 , with C-His labeled tag.
- Application
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别名
Keratan sulfate proteoglycan osteomodulin; OSAD; OMD; SLRR2C
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种属
Mouse
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表达系统
HEK293
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标签
C-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O35103
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表达区间
M1-I423
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蛋白长度
Full Length
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分子量
60-70 kDa.
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Osteomodulin, a small leucine-rich proteoglycan (SLRP), is primarily expressed in bone and cartilage tissues and plays a crucial role in the regulation of extracellular matrix organization and mineralization. Its involvement in bone development and remodeling makes it a significant focus of research in orthopedics and regenerative medicine. Studies have indicated that osteomodulin interacts with collagen and other matrix proteins, contributing to the mechanical properties and structural integrity of bone. Furthermore, it has been linked to various pathological conditions, including osteoporosis and osteoarthritis, where its expression is altered. The recombinant expression of osteomodulin allows for the detailed study of its biological functions and interactions at a molecular level. Researchers aim to produce osteomodulin in vitro, facilitating investigations into its role in cellular processes such as proliferation, differentiation, and mineral deposition. Understanding osteomodulin's function could provide insights into new therapeutic strategies for bone-related diseases and enhance tissue engineering approaches for bone regeneration. The production and characterization of osteomodulin recombinant proteins ultimately pave the way for exploring its potential applications in clinical settings and the development of biomaterials that mimic the natural bone environment.
