Analytical Data
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Gene name
DSN1
- Application
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Alternative Names
C20orf172; Chromosome 20 open reading frame 172; dJ469A13.2; DSN1; DSN1; MIND kinetochore complex component; homolog; DSN1; MIND kinetochore complex component; homolog (S. cerevisiae); DSN1; MIS12 kinetochore complex component; DSN1_HUMAN; FLJ13346; hKNL-3; Kinetochore associated protein DSN1; Kinetochore associated protein DSN1 homolog; Kinetochore null 3 homolog; Kinetochore-associated protein DSN1 homolog; KNL3; MGC32987; MIS13
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Species
Human
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Source
E. coli
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Tag
N- GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9H410
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Expression Region
1-356aa
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Molecular Weight
67.1 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
DSN1 is a crucial protein component of the Ndc80 complex, which plays a significant role in the assembly of the kinetochore, a structure essential for accurate chromosome segregation during cell division. Research on DSN1 has gained momentum due to its involvement in various cellular processes, including the maintenance of genomic stability and the regulation of mitosis. Mutations or dysregulation of DSN1 can lead to improper chromosome segregation, which is implicated in several diseases, particularly cancer. Understanding the structure and function of DSN1, as well as its interactions with other kinetochore proteins, can provide invaluable insights into the mechanisms governing cell division and the development of potential therapeutic strategies. Additionally, DSN1's evolutionary conservation across species underscores its fundamental role in cellular biology. The ongoing investigations into the molecular mechanisms by which DSN1 contributes to kinetochore function aim to unravel the complexities of mitotic regulation and offer prospects for interventions in diseases characterized by mitotic errors.
